NAD+ (nicotinamide adenine dinucleotide) is a vital molecule for life. It is involved in cell signaling, redox reactions, and energy production. As we age, our body’s ability to produce and recycle NAD+ declines, despite adequate nutrition. Supplements, particularly NMN, can enhance NAD+ levels, potentially promoting longevity and health.

NAD+ Metabolism and Aging

NAD+ production decreases with age, while the enzyme NADase, particularly CD38, which depletes NAD+, increases. High levels of CD38 are linked to chronic inflammation and diseases such as heart disease, diabetes, and cancer. Enhancing NAD+ and inhibiting CD38 can support health and longevity.

NAD+ Supplements

Nicotinamide Riboside (NR): can boost NAD+. Recommended doses are 100-300 mg daily.

ß-Nicotinamide Mononucleotide (NMN): is believed to be more effective than NR.

Lower doses and sublingual forms of these supplements are often more effective due to better absorption.

NAD+ IV Therapy Intravenous NAD+ therapy bypasses digestive barriers, providing immediate benefits such as improved mood and energy. Safe doses range from 250 to 750 mg, administered slowly over several hours. IV therapy is gaining popularity for anti-aging and treating conditions like chronic fatigue and autoimmune disorders.

Diet and Lifestyle for NAD+ Maintaining adequate niacin (vitamin B3) and tryptophan in the diet supports NAD+ production. Niacin-rich foods include meats, fish, legumes, and seeds. Intermittent fasting and ketogenic diets can also boost NAD+ by activating sirtuins, which are crucial for metabolism and longevity.

Benefits of Increasing NAD+ Higher NAD+ levels support sirtuin pathways, potentially delaying aging. Other benefits include improved brain function, heart health, immune response, liver function, and insulin sensitivity. NAD+ also helps restore telomere length, crucial for cellular aging.

Conclusion To promote healthy aging, consider NMN supplements and IV therapy for a greater boost, along with a balanced diet and regular exercise. This proactive approach can enhance your healthspan and increase your chances of living a long, healthy life!

With permission from Dr. J.E. Williams